Log In

Steven Sloan, M.D., Ph.D. Steven Sloan, M.D., Ph.D.

Associate Professor of Pathology
Harvard Medical School
Medical Director, Pediatric Transfusion Medicine
Children's Hospital Boston

Contact information

Joint Program in Transfusion Medicine & Dept. Laboratory Medicine
Children's Hospital Boston - Blood Bank 406
300 Longwood Ave.
Boston, MA 02115
Phone: 617-355-6268


M.D., Ph.D., 1990, New York University

Research Interests

The goal of my research is to understand intracellular signaling and regulation of transcription in B lymphocytes during immune responses. When cell surface immunoglobulin on a B lymphocyte binds to an antigen, it secretes chemokines that attract cells such as helper T cells. These helper T cells foster the development of the B cells into productive antibody secreting cells.

The MIP-1b chemokine is one of the most important chemokines that is secreted by B cells to attract T cells. We are studying means by which its expression is enhanced in antigen stimulated B cells. The MIP-1b gene is only minimally transcribed in unstimulated B cells and its transcription dramatically increases shortly after the B cells are stimulated. The mechanism by which this transcription increases is not currently known but recent experiments indicate that at least one transcription factor binds upstream of the MIP-1b gene. We are currently performing experiments to identify that factor and elucidate mechanisms by which that factor is activated in antigen stimulated B cells.

Home | Application | Conferences | Coverage | Clinical Trials | Curriculum
Faculty | Links | Manuals | Lectures | Resources | NHSN | | Rotations | Trainees

Homepage: https://www.harvardtransfusion.org
© 2005 - 2021 Harvard Medical School Fellowship Program in Transfusion Medicine. All rights reserved.